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Prof. Dr. Markus Nett

Prof. Dr. Markus Nett Foto von Prof. Dr. Markus Nett

Telefon
(+49)231 755-4742

Sprechzeiten
In der Vorlesungszeit Mittwochs von 9.00 bis 11.00Uhr
Bitte vorher anmelden unter folgender Email: bio_sek@bci.tu-dortmund.de

Adresse

Raum G1-621

Inhalt

Wissenschaftlicher Werdegang

seit 2016 Professur für Technische Biologie, Technische Universität Dortmund

2014 Gastprofessur für Pharmakognosie, Universität Wien

2014 Habilitation in Pharmazie, Friedrich-Schiller-Universität Jena

seit 2009 Leiter einer Nachwuchsforschergruppe, Leibniz Institut für Naturstoff-Forschung und Infektionsbiologie – Hans-Knöll-Institut (HKI) Jena

2007-2008 Wiss. Mitarbeiter, Scripps Institution of Oceanography, Center for Marine Biotechnology and Biomedicine, San Diego, USA, gefördert durch ein DAAD-Postdoktoranden-Stipendium

2007 Promotion in Pharmazie, Rheinische Friedrich-Wilhelms-Universität Bonn

2002 Approbation als Apotheker

1997-2001 Studium der Pharmazie, Rheinische Friedrich-Wilhelms-Universität Bonn

Publikationen

   

Beiträge in wissenschaftlichen Fachzeitschriften

2019

J. Diettrich, H. Kage, M. Nett

Genomics-inspired discovery of massiliachelin, an agrochelin epimer from Massilia sp. NR 4-1

Beilstein J Org Chem 15, 1298-1303 (2019)


E. Geib, F. Baldeweg, M. Doerfer, M. Nett, M. Brock

Cross-chemistry leads to product diversity from atromentin synthetases in Aspergilli from section Nigri

Cell Chem Biol 26, 223-234 (2019)


C. Kurth, I. Wasmuth, T. Wichard, G. Pohnert, M. Nett

Algae induce siderophore biosynthesis in the freshwater bacterium Cupriavidus necator H16

Biometals 32, 77-88 (2019)


F. Baldeweg, D. Hoffmeister, M. Nett

A genomics perspective on natural product biosynthesis in plant pathogenic bacteria

Nat Prod Rep 36, 307-325 (2019)

      

2018

E. Geib F. Baldeweg M. Doerfer M. Nett M. Brock

Cross-Chemistry Leads to Product Diversity from Atromentin Synthetases in Aspergilli from Section Nigri

Cell Chem Biol (2018) https://doi.org/10.1016/j.chembiol.2018.10.021

Kurth, C., Wasmuth, I., Wichard, T., Pohnert, G. & Nett, . BioMetals 6, (2018).

Algae induce siderophore biosynthesis in the freshwater bacterium Cupriavidus necator H16

BioMetals 6 (2018) https://doi.org/10.1007/s10534-018-0159-6

J. Korp, L. Winand, A. Sester, M. Nett

Engineering pseudochelin production in Myxococcus xanthus

Appl Environ Microbiol, doi: 10.1128/AEM.01789-18 (2018)

 

F. Baldeweg, D. Hoffmeister, M. Nett

A genomics perspective on natural product biosynthesis in plant pathogenic bacteria

Nat Prod Rep, doi: 10.1039/c8np00025e (2018)

  

2017 

X. Pan, N. Domin, S. Schieferdecker, H. Kage, M. Roth, M. Nett

Herpetopanone, a diterpene from Herpetosiphon aurantiacus discovered by isotope labeling

Beilstein J Org Chem, 13, 2458-2465 (2017)

            

F. Baldeweg, H. Kage, S. Schieferdecker, C. Allen, D. Hoffmeister, M. Nett

Structure of ralsolamycin, the interkingdom morphogen from the crop plant pathogen Ralstonia solanacearum

Org Lett 19, 4868-4871 (2017)

     

X. Pan, H. Kage, K. Martin, M. Nett

Herpetosiphon gulosus sp. nov., a filamentous predatory bacterium isolated from sandy soil and Herpetosiphon giganteus sp. nov., nom. rev.

Int J Syst Evol Microbiol 67, 2476-2481 (2017)

     

P. Brandt, M. García-Altares, M. Nett, C. Hertweck, D. Hoffmeister

Induced chemical defense of a mushroom by a double-bond-shifting polyene synthase

Angew Chem Int Ed 56, 5937-5941 (2017)

                                                   

V. Valiante, D. J. Mattern, A. Schüffler, F. Horn, G. Walther, K. Scherlach, L. Petzke, J. Dickhaut, R. Guthke, C. Hertweck, M. Nett, E. Thines, A. A. Brakhage

Discovery of an extended austinoid biosynthetic pathway in Aspergillus calidoustus

ACS Chem Biol 12, 1227-1234 (2017)

        

S. Schieferdecker, S. König, S. Pace, O. Werz, M. Nett

Myxochelin-inspired 5-lipoxygenase inhibitors: synthesis and biological evaluation                                                                                                         

ChemMedChem 12, 23-27 (2017)  

   

2016 

D. Braga, D. Hoffmeister, M. Nett                                                                                                 

A  non-canonical peptide synthetase adenylates 3-methyl-2-oxovaleric acid for auriculamide biosynthesis                                                        

Beilstein J Org Chem 12, 2766-2770 (2016)

    

E. Walther, S. Boldt, H. Kage, T. Lauterbach, K. Martin, M. Roth, C. Hertweck, A. Sauerbrei, M. Schmidtke, M. Nett

Zincophorin – biosynthesis in Streptomyces griseus and antibiotic properties                         

GMS Infectious Diseases 4, 08.20161128 (2016)

    

I. Seccareccia, A. T. Kovacs, R. Gallegos-Monterrosa, M. Nett                                        

Unraveling the predator-prey relationship of Cupriavidus necator and Bacillus subtilis 

Microbiol Res 192, 231-238 (2016)

 

C. Kurth, H. Kage, M. Nett                                                                                     

Siderophores as molecular tools in medical and environmental applications           

Org Biomol Chem 14, 8212-8227 (2016)

 

D. Kalb, T. Heinekamp, S. Schieferdecker, M. Nett, A. A. Brakhage, D. Hoffmeister                   

An iterative O-methyltransferase catalyzes 1,11-dimethylation of Aspergillus fumigatus fumaric acid amides

ChemBioChem 17 (19), 1813-1817 (2016)

 

J. Korp, M. S. Vela-Gurovic, M. Nett                                                                        

Antibiotics from predatory bacteria                                                                                    

Beilstein J Org Chem 12, 594-607 (2016)

 

A. M. Schaible, R. Filosa, V. Krauth, V. Temml, S. Pace, U. Garscha, S. Liening, C. Weinigel, S. Rummler, S. Schieferdecker, M. Nett, A. Peduto, S. Collarile, M. Scuotto, F. Roviezzo, G. Spaziano, M. de Rosa, H. Stuppner, D. Schuster, B. D'Agostino, O. Werz                                                                               

The 5-lipoxygenase inhibitor RF-22c potently suppresses leukotriene biosynthesis in cellulo and blocks bronchoconstriction and inflammation in vivo 

Biochem Pharmacol 112, 60-71 (2016)                                                                                                                                         

                                                                         

D. Schwenk, P. Brandt, R. A. Blanchette, M. Nett, D. Hoffmeister                                    

Unexpected metabolic versatility in a combined fungal fomannoxin/vibralactone biosynthesis                                                                                                                                                       

J Nat Prod 79, 1407-1414 (2016)                                                                                                                                                                                      

                                                                                       

C. Kurth, S. Schieferdecker, K. Athanasopoulou, I. Seccareccia, M. Nett                            

Variochelins, lipopeptide siderophores from Variovorax boronicumulans discovered by genome mining                                                                                                

J Nat Prod 79, 865-872 (2016)

                                

S. Schieferdecker, M. Nett                                                                                                          

A fast and efficient method for the preparation of the 5-lipoxygenase inhibitor myxochelin A                                                                                            

Tetrahedron Lett 57, 1359-1360 (2016)

                                                        

2015

H. Kage, E. Riva, J. S. Parascandolo, M. F. Kreutzer, M. Tosin, M. Nett                          

Chemical chain termination resolves the timing of ketoreduction in a partially reducing iterative type I polyketide synthase

Org Biomol Chem 13, 11414-11417 (2015)

                                       

J. S. Bauer, M. G. K. Ghequire, M. Nett, M. Josten, H.-G. Sahl, R. De Mot, H. Gross

Biosynthetic origin of the antibiotic pseudopyronines A and B in Pseudomonas putida BW11M1                                                                                                

ChemBioChem 16, 2491-2497 (2015)

                                          

J. Korp, S. König, S. Schieferdecker, H.-M. Dahse, G. M. König, O. Werz, M. Nett

Harnessing enzymatic promiscuity in myxochelin biosynthesis for the production of 5-lipoxygenase inhibitors                                                                              

ChemBioChem 16, 2445-2450 (2015)

                               

M. H. Medema, R. Kottmann, P. Yilmaz, ..., M. Nett, …, R. Breitling, E. Takano, F. O. Glöckner                            

Minimum information about a biosynthetic gene cluster

Nat Chem Biol 11, 625-631 (2015)

                                              

I. Seccareccia, C. Kost, M. Nett                                                                                         

Quantitative analysis of Lysobacter predation                                                              

Appl Environ Microbiol 81, 7098-7105 (2015)

                                                   

S. Schieferdecker, N. Domin, C. Hoffmeier, D. A. Bryant, M. Roth, M. Nett                    

Structure and absolute configuration of auriculamide, a natural product from the predatory bacterium Herpetosiphon aurantiacus 

Eur J Org Chem 14, 3057-3062 (2015)

 

E. C. Barnes, P. Bezerra-Gomes, M. Nett, C. Hertweck                                                   

Dandamycin and chandrananimycin E, benzoxazines from Streptomyces griseus               

J Antibiot 68, 463-468 (2015)

                                                  

S. Schieferdecker, S. König, A. Koeberle, H.-M. Dahse, O. Werz, M. Nett                     

Myxochelins target human 5-lipoxygenase                                                                      

J Nat Prod 78, 335-338 (2015)

                                                    

2014

D. Schwenk, M. Nett, H.-M. Dahse, U. Horn, R. A. Blanchette, D. Hoffmeister                      

Injury-induced biosynthesis of methyl-branched polyene pigments in a white-rotting basidiomycete                                                                                                   

J Nat Prod 77, 2658-2663 (2014)

                             

M. Nett                                                                                                                                        

Genome mining: concept and strategies for natural product discovery                       

Prog Ch Org Nat Prod 99, 199-245 (2014)

                                                                                                                                 

S. Schieferdecker, S. König, C. Weigel, H.-M. Dahse, O. Werz, M. Nett                             

Structure and biosynthetic assembly of gulmirecins, macrolide antibiotics from the predatory bacterium Pyxidicoccus fallax                                                  

Chem Eur J 20, 15933-15940 (2014)

                      

J. Pauly, M. Nett, D. Hoffmeister                                                                               

Ralfuranone is produced by an alternative aryl-substituted γ-lactone biosynthetic route in Ralstonia solanacearum

J Nat Prod 77, 1967-1971 (2014)

                         

S. Schieferdecker, T. Exner, H. Gross, M. Roth, M. Nett                                                            

New myxothiazols from the predatory bacterium Myxococcus fulvus                            

J Antibiot 67, 519-525 (2014)

                      

C. Otzen, B. Bardl, I. D. Jacobsen, M. Nett, M. Brock                                                           

Candida albicans utilises a modified β-oxidation pathway for the degradation of toxic propionyl-CoA                                                                                                     

J Biol Chem 289, 8151-8169 (2014)

                              

M. F. Kreutzer, H. Kage, J. Herrmann, J. Pauly, R. Hermenau, R. Müller, D. Hoffmeister, M. Nett                                                                                                 

Precursor-directed biosynthesis of micacocidin derivatives with activity against Mycoplasma pneumoniae                                                                                        

Org Biomol Chem 12, 113-118 (2014)   

                                                                                        

2013
C. E. Elliott, D. L. Callahan, D. Schwenk, M. Nett, D. Hoffmeister, B. J. Howlett 

A gene cluster responsible for biosynthesis of phomenoic acid in the plant pathogenic fungus, Leptosphaeria maculans

Fungal Genet Biol 53, 50-58 (2013)

                              

V. M. S. Gurovic, S. Müller, N. Domin, I. Seccareccia, S. Nietzsche, K. Martin, M. Nett

Micromonospora schwarzwaldensis sp. nov., a producer of telomycin, isolated from soil

Int J Syst Evol Microbiol 63, 3812-3817 (2013)

                                 

H. Kage, M. F. Kreutzer, B. Wackler, D. Hoffmeister, M. Nett

An iterative type I polyketide synthase initiates the biosynthesis of the antimycoplasma agent micacocidin

Chem Biol 20, 764-771 (2013)

                                    

R. D. Kersten, A. L. Lane, M. Nett, T. K. Richter, B. M. Duggan, P. C. Dorrestein, B. S. Moore

Bioactivity-guided genome mining reveals the lomaiviticin biosynthetic gene cluster in Salinispora tropica

ChemBioChem 14, 955-962 (2013)

                         

J. Pauly, D. Spiteller, J. Linz, J. Jacobs, C. Allen, M. Nett, D. Hoffmeister

Ralfuranone thioether production by the plant pathogen Ralstonia solanacearum

ChemBioChem 14, 2169-2178 (2013)    

            

2012
S. Kastner, S. Müller, L. Natesan, G. M. König, R. Guthke, M. Nett

4-Hydroxyphenylglycine biosynthesis in Herpetosiphon aurantiacus: a case of gene duplication and catalytic divergence

Arch Microbiol 194, 557-566 (2012)

                         

M. F. Kreutzer, H. Kage, M. Nett

Structure and biosynthetic assembly of cupriachelin, a photoreactive siderophore from the bioplastic producer Cupriavidus necator H16

J Am Chem Soc 134, 5415-5422 (2012)

                                

M. F. Kreutzer, M. Nett

Genomics-driven discovery of taiwachelin, a lipopeptide siderophore from Cupriavidus taiwanensis

Org Biomol Chem 10, 9338-9343 (2012)

                              

M. Roth, K. Martin, E. Zang, M. Nett, T. Henkel

A microfluidics-based approach to drug discovery

Biomed Tech 57(SI-1 Track-B), 270 (2012)

                                   

2011
M. Bohnert, S. Miethbauer, H. M. Dahse, J. Ziemen, M. Nett, D. Hoffmeister

In vitro cytotoxicity of melleolide antibiotics: structural and mechanistic aspects

Bioorg Med Chem Lett 21, 2003-2006 (2011)

                               

H. Kiss, M. Nett, N. Domin, K. Martin, J. A. Maresca, A. Copeland, A. Lapidus, S. Lucas, K. W. Berry, T. Glavina Del Rio, E. Dalin, H. Tice, S. Pitluck, P. Richardson, D. Bruce, L. Goodwin, C. Han, J. C. Detter, J. Schmutz, T. Brettin, M. Land, L. Hauser, N. C. Kyrpides, N. Ivanova, M. Göker, T. Woyke, H. P. Klenk, D. A. Bryant

Complete genome sequence of the filamentous gliding predatory bacterium Herpetosiphon aurantiacus type strain (114-95(T))

Stand Genomic Sci 5, 356-370 (2011) 

                               

M. F. Kreutzer, H. Kage, P. Gebhardt, B. Wackler, H. P. Saluz, D. Hoffmeister, M. Nett

Biosynthesis of a complex yersiniabactin-like natural product via the mic locus in phytopathogen Ralstonia solanacearum

Appl Environ Microbiol 77, 3617-3625 (2011) 

                           

M. Nett, C. Hertweck

Farinamycin, a quinazoline from Streptomyces griseus

J Nat Prod 74, 2265-2268 (2011)

                                          

D. W. Udwary, E. A. Gontang, A. C. Jones, C. S. Jones, A. W. Schultz, J. M. Winter, J. Y. Yang, N. Beauchemin, T. L.  Capson, B. R. Clark, E. Esquenazi, A. S. Eustáquio, K. Freel, L. Gerwick, W. H. Gerwick, D. Gonzalez, W. T. Liu, K. L.  Malloy, K. N. Maloney, M. Nett, J. K. Nunnery, K. Penn, A. Prieto-Davo, T. L. Simmons, S. Weitz, M. C. Wilson, L. S. Tisa, P. C. Dorrestein, B. S. Moore

Significant natural product biosynthetic potential of actinorhizal symbionts of the genus Frankia, as revealed by comparative genomic and proteomic analyses

Appl Environ Microbiol 77, 3617-3625 (2011) 

                                  

B. Wackler, P. Schneider, J. M. Jacobs, J. Pauly, C. Allen, M. Nett, D. Hoffmeister

Ralfuranone biosynthesis in Ralstonia solanacearum suggests functional divergence in the quinone synthetase family of enzymes

Chem Biol 18, 354-360 (2011) 

                             

2010
P. B. Gomes, M. Nett, H. M. Dahse, I. Sattler, K. Martin, C. Hertweck

Bezerramycins A-C, antiproliferative phenoxazinones from Streptomyces griseus featuring carboxy, carboxamide or nitrile substituents

Eur J Org Chem, 231-235 (2010)

                            

P. B. Gomes, M. Nett, H. M. Dahse, C. Hertweck

Pitucamycin: structural merger of a phenoxazinone with an epoxyquinone antibiotic

J Nat Prod 73, 1461-1464 (2010)  

                 

2009
M. Nett, T. A. Gulder, A. J. Kale, C. C. Hughes, B. S. Moore

Function-oriented biosynthesis of beta-lactone proteasome inhibitors in Salinispora tropica

J Med Chem 52, 6163-6167 (2009) 

                           

M. Nett, H. Ikeda, B. S. Moore

Genomic basis for natural product biosynthetic diversity in the actinomycetes

Nat Prod Rep 26, 1362-1384 (2009) 

                            

M. Nett, B. S. Moore

Exploration and engineering of biosynthetic pathways in the marine actinomycete Salinispora tropica

Pure Appl Chem 81, 1075-1084 (2009)

                                

K. Penn, C. Jenkins, M. Nett, D. W. Udwary, E. A. Gontang, R. P. McGlinchey, B. Foster, A. Lapidus, S. Podell, E. E. Allen, B. S. Moore, P. R. Jensen

Genomic islands link secondary metabolism to functional adaptation in marine Actinobacteria

ISME 3, 1193-1203 (2009) 

                                    

P. Schneider, J. M. Jacobs, J. Neres, C. C. Aldrich, C. Allen, M. Nett, D. Hoffmeister

The global virulence regulators VsrAD and PhcA control secondary metabolism in the plant pathogen Ralstonia solanacearum

ChemBioChem 10, 2730-2732 (2009) 

                     

2008
R. P. McGlinchey, M. Nett, A. S. Eustáquio, R. N. Asolkar, W. Fenical, B. S. Moore

Engineered biosynthesis of antiprotealide and other unnatural salinosporamide proteasome inhibitors

J Am Chem Soc 130, 7822-7823 (2008) 

                           

R. P. McGlinchey, M. Nett, B. S. Moore

Unraveling the biosynthesis of the sporolide cyclohexenone building block

J Am Chem Soc 130, 2406-2407 (2008) 

             

2007
M. Nett, G. M. König

The chemistry of gliding bacteria

Nat Prod Rep 24, 1245-1261 (2007)

                         

2006
M. Nett, O. Erol, S. Kehraus, M. Köck, A. Krick, E. Eguereva, E. Neu, G. M. König

Siphonazole, an unusual metabolite from Herpetosiphon sp.

Angew Chem Int Ed 45, 3863-3867 (2006)

                    

2003

H. Gross, S. Kehraus, M. Nett, G. M. König, W. Beil, A. D. Wright

New cytotoxic cembrane based diterpenes from the soft corals Sarcophyton cherbonnieri and Nephthea sp.

Org Biomol Chem 1, 944-949 (2003)

                            

                  
Beiträge in nicht begutachteten Fachzeitschriften und Buchkapitel


M. Nett*

Genome mining – concept and strategies for natural product discovery

Progress in the Chemistry of Organic Natural Products, edited by Kinghorn DA, Falk H, Kobayashi J, Vol. 99, Springer Switzerland, 199-245 (2014) 

                            

M. Nett*, M. Roth, T. Henkel

Genomics meets microfluidics

GENOMXPRESS 2.11, 8-9 (2011) 

                              

M. Nett, D. Fenske*

Substitution von Betablockern

Krankenhauspharmazie 23, 509-51 (2002)