Sprungmarken

Servicenavigation

Hauptnavigation

Sie sind hier:

Hauptinhalt

M.Sc. Amelie Mattusch

M.Sc. Amelie Mattusch Foto von M.Sc. Amelie Mattusch

Telefon
(+49)231 755-2108

Adresse

Raum G3-4.12

Inhalt

Abstract

A major challenge in the development of drug formulations is the low aqueous solubility of the active pharmaceutical ingredient (API) molecules and its resulting low bioavailability.[1]  A conventional approach to increase the solubility in water is e.g. the reduction of the particle size.[2] In addition to the solubility, the dissolution performance represents a crucial parameter in the pharmaceutical industry.

Description

For many years, only diffusion models were used to describe drug dissolution. Recent observations also describe the effect of drug-solvent interactions in drug release in addition to diffusion effects. Regarding the dissolution mechanism, a more detailed understanding of the dissolution process is desirable.

In this study, a specially developed release device is used and the dissolution behavior of different active substances is investigated. Thus, an identification of suitable formulation strategies could follow, depending on the rate limiting step.

  

[1] Lipinski, C., 2002. Poor aqueous solubility – an Industry Wide Problem in Drug Discovery. Am Pharm Rev 5, 82-85

[2] Khadka, P., Ro, J., Kim, H., Kim, I., Kim, J.T., Kim, H., Cho, J.M., Yun, G., Lee, J., 2014. Pharmaceutical particle technologies: An approach to improve drug solubility, dissolution and bioavailability. Asian Journal of Pharmaceutical Sciences 9 (6), 304-316

Curriculum Vitae

since 2019 PhD at the Laboratory of Solids Process Engineering, TU Dortmund
2017-2018

M.Sc. Biochemical Engineering, TU Dortmund
Master thesis: Investigation of Interparticle- and Particle-Wall-Contacts to Describe Mass Transfer in Spheronization

2013-2017

B.Sc. Biochemical Engineering, TU Dortmund
Bachelor thesis: Rapid Screening for Dinucleotide Activity Using In-vitro Protein Synthesis

2005-2013

Pestalozzi Gymnasium, Unna

Born May 16th, Unna (Germany)