Sprungmarken

Servicenavigation

Hauptnavigation

Sie sind hier:

Hauptinhalt

M. Sc. Mpho Prudence Setlhaku

M. Sc. Mpho Prudence Setlhaku Foto von M. Sc. Mpho Prudence Setlhaku

Telefon
(+49)231 755-5109

Fax
(+49)231 755-5110

Adresse

Arbeitsgruppe Bioverfahrenstechnik
Emil-Figge-Straße 66
44227 Dortmund
Deutschland

Campus Adresse
Campus Nord
Geschossbau 1, 6. Etage

Raum 524

Details

PhD Project

The predicted shortage, coupled with a rise in demand and subsequently surging prices of fossil fuels provide a good and necessary platform for the development of alternative bio-chemicals. Some of which can be used for renewable energy sources, like n-butanol. Currently butanol is produced via the petrochemical route and it is used as a precursor for acrylates and acrylate esters, which are used as coating materials, lacquers, solvents and cosmetics.

Biotechnological production of butanol, also known as Acetone-Butanol-Ethanol (ABE) process, through the anaerobic fermentation of mainly Clostridium acetobutylicum and Clostridium beijerinckii bacteria has seen great research interest due to the potential of butanol. To date, the fermentative butanol production is uneconomical due to high substrate costs, complex clostridia metabolism, ineffective production process and energy intensive downstream processing.

The main objective of this PhD project is to develop and optimize a production process for butanol via the fermentation of C. acetobutylicum.

Publications

Articles:

2012

Mpho Setlhaku, Sina Brunberg, Eva del Amor Villa, Rolf Wichmann

Improvement in the bioreactor specific productivity by coupling continuous reactor with repeated fedbatch reactor for acetone–butanol–ethanol production 

Journal of Biotechnology, DOI-Link

Conferences:

2012

Novel Process Concept Developed for Biobutanol Production

M.P. Setlhaku, E. M del Amor Villa, R. Wichmann

Poster presentation: CLIB Retreat 3, Bergisch Gladbach, Germany

2011

Process Development for Continuous Biobutanol Production

M.P. Setlhaku, E. M del Amor Villa, R. Wichmann

Presentation and Poster: CLIB Retreat 2, Bonn (Germany), April 2011

Biobutanol production using repeated batch with immobilized cells: process alternative to continuous

M.P. Setlhaku, E. M del Amor Villa, R. Wichmann

Presentation: Bioengineering III conference, Lanzarote (Canary Island), May 2011

Repeated Batch vs. Continuous Fermentation for Butanol Production

M.P. Setlhaku, E. M del Amor Villa, R. Wichmann

Presentation: RRB 7conference, Brugge (Belgium), June 2011

Acetone-butanol-ethanol fermentation process improvement using continuous two-stage reactor system with cell immobilization

M.P. Setlhaku, E. M del Amor Villa, R. Wichmann,

Presentation: ECAB-ECCE, Berlin (Germany), September 2011

2010

Development and optimization of the continuous fermentation process for butanol production

M.P. Setlhaku, E. M del Amor Villa, R. Wichmann

Poster presentation: CLIB Retreat 1, Wuppertal (Germany), May 2010

Novel butanol production using a loofa sponge immobilized cell bioreactor

M.P. Setlhaku, E. M del Amor Villa, R. Wichmann

Poster presentation: RRB 6 conference, Düsseldorf (Germany), June 2010

Continuous butanol production with free and immobilized Clostridium acetobutylicum

M.P. Setlhaku, E. M del Amor Villa, R. Wichmann,

Poster presentation: ESBES-ISPPP–Biothermodynamics, Bologna (Italy), August 2010

References

Dürre, P., 2011. Fermentative production of butanol- the academic perspective. Curr. Opin. Biotech. 22, 1 – 6

Lee S. Y., Park J. H., Jang S. H. Nielsen S. K., Kim J., Jung K. S., 2008. Fermentative butanol production by Clostridia. Biotech. Bioeng. 101, 209 – 228

Woods, D.R., Jones, D.T., 1986. Acetone-butanol fermentation revisited. Microbiol. Rev. 50, 484 – 524

"This research has received funding from the Ministry of Innovation, Science and Research of North Rhine-Westphalia in the frame of CLIB-Graduate Cluster Industrial Biotechnology, contract no: 314 - 108 001 08".