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PhD

Philipp Nerke Foto von Philipp Nerke

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(+49)231 755-5475

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Raum G1 6.20

Project

Abstract:
The key advantage of biocatalysis is the outstanding regio- and stereospecificity [1]. Biocatalysts have been shown to be efficient catalysts for reactions which otherwise require harsh reaction conditions, like C‑H‑hydroxylations. Generally, biocatalysts can be employed as enzymes in cell‑free systems or as the whole cell being the catalyst. Cell‑free systems are often used for one‑step biotransformations, while whole‑cell systems are used for fermentations or when co‑factor regeneration is required [2].

Description:
This project focuses on the production of industrially relevant chemicals utilizing whole‑cell biocatalysts and renewable feedstocks. The cells metabolism is exploited for regeneration of the needed co‑substrate. Following an integrated process development approach sets the basis for an efficient scale‑up and downstream processing.

 Figure_Homepage

Figure: Schematic presentation of the whole-cell biocatalyst used in this work.


[1] Bommarius, A. S. (2015) Biocatalysis: A Status Report. Annu. Rev. Chem. Biomol. Eng. 6, 319–345.
[2] Schrewe, M., Julsing, M. K., Bühler, B. & Schmid, A. (2013) Whole-cell biocatalysis for selective and productive C-O functional group introduction and modification. Chem. Soc. Rev. 42, 6346–77.

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Funding

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